Paracetamols are better than NSAIDS

Analgesics are the class of drugs which is used to achieve an analgesia that is relief from pain.

Major categories of analgesic drugs are:

NSAIDs
Acetamineophen/PCM
Flupirtine
Zinconotide

The advancements in the field of molecular biology, achieved great heights. Understanding of different action mechanisms followed by the drug discoveries became easier.

Paracetamol, the most commonly used anti-pyretic drug, has also been considered as an analgesic which showed better results in comparison to the other analgesics used to provide relief from body pains.

Structure of paracetamol

This drug has no significant action on the enzymes COX-1 and COX-2, the enzymes responsible for causing pain and other complications in out body. Recent research has shown the presence of unknown cyclooxygenase enzyme COX-3, found in brain and spinal cord which is selectively inhibited by paracetamol and is distinct from the other two known cyclooxygenase enzymes: COX-1 and COX-2. Selective inhibition of the enzyme COX-3 in the brain and spinal cord explains the effectiveness of paracetamol in relieving pain and reducing fever without having unwanted gastrointestinal side effects.

The analgesic action of paracetamol is central and is due to the activation of
descending serotonergic pathways.

Non-narcotic analgesics are mainly used for treating patients, suffering from hemophilia, peptic ulcer disease and also for those who take moderate dosage of uricosuric drugs.